MOTS-C
Full description
MOTS-C is a mitochondrial-derived peptide extensively researched for its ability to regulate energy metabolism, enhance insulin sensitivity, and mimic the metabolic benefits of physical exercise.
What is it used for? (Primary Research Applications)
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) acts as a mitochondrial hormone that translocates to the cell nucleus to regulate gene expression in response to metabolic stress. Key research domains include:
- Metabolic Regulation & Weight Management: Promotes fatty acid oxidation and prevents high-fat diet-induced body weight accumulation.
- Insulin Sensitivity: Significantly improves glucose uptake in skeletal muscle and reverses insulin resistance.
- Exercise Mimetic Properties: Activates the AMPK metabolic pathway, enhancing physical endurance, aerobic capacity, and muscle performance.
- Longevity & Cellular Health: Protects cells against oxidative stress and age-related metabolic decline.
Long Description & Mechanism of Action
Unlike most peptides encoded in the nuclear genome, MOTS-C is encoded directly within the mitochondrial genome. This positions it as a vital regulator of systemic cellular homeostasis and inter-organelle communication between mitochondria and the nucleus. It is a fundamental tool for research into metabolic disorders, type 2 diabetes, obesity, and anti-aging science.
Technical Specifications
- Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
- Molecular Formula: C101H152N28O22S2
- Purity: ≥ 99% (HPLC)
- Form: Lyophilized powder (Sterile laboratory grade)
Shipping & cold chain
All orders ship with thermally monitored packaging to preserve product integrity in transit.
Storage
Store lyophilized vials between 2°C and 8°C for short-term handling, or frozen at -20°C for long-term preservation.
For research use only.